Introduction

Understanding protein-ligand interactions is pivotal for ­­­accelerating lead identification and structure guided lead optimisation. Our team of experts at the Protein Structure & Biophysics (PSB) platform support the determination of high-resolution structures of proteins and protein-ligand complexes.

The PSB team provides solutions tailored to your needs starting from construct design, protein expression & purification, HTS for crystal hit identification & optimisation of crystallisation conditions to atomic structure solution. The PSB team has access to both in-house diffractometers and commercial beamline at synchrotrons to provide fast turnaround to your projects. Experienced crystallographers with expertise on various target proteins will work together with the clients.

Key Services

Construct Design and Optimisation

Protein Expression and Purification

Crystallisation Screens & Crystal Optimisation

Protein – Ligand Complex & Crystallisation and Analysis

We also provide end-to-end service for:

• Epitope mapping for antigen-antibody interactions
• High throughput fragment screening (FBDD)

Our Experts

EARO Director, Christophe Bodenreider
Head of PSB, Nithya Baburajendran
Senior Research Fellow, Jothi Anantharajan
Research Associate, Yeo Yee Khoon